By Cody J. Locke, Kim A. Caldwell, Guy A. Caldwell (auth.), Scott C. Baraban (eds.)
With its complicated anatomical, molecular, electrophysiological and behavioral parts, epilepsy offers the neuroscientist with approximately boundless possibilities to check easy neurobiological mechanisms. In Animal types of Epilepsy: equipment and Innovations, admired investigators within the box learn a number of novel types of epilepsy in mice in addition to in genetically tractable "simple" species equivalent to Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). whereas protecting a few conventional types, the amount additionally explores the most recent concepts like modeling seizure task in silica and complex recommendations for seizure detection and gene treatment. As a quantity within the profitable Neuromethods™ sequence, the chapters offer transparent, step by step protocols and thought-provoking experiences of the latest developments within the field.
Comprehensive and state-of-the-art, Animal types of Epilepsy: equipment and Innovations is a perfect advisor for scientists who desire to extend our realizing of the pathogenesis of this neurological disorder.
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Extra info for Animal Models of Epilepsy: Methods and Innovations
Similar reductions of bss recovery time are observed by feeding two other phytochemicals that are potent top1 inhibitors, apigenin and kaempferol (26). Electrophysiological recordings corroborate these behavioral results. CPT treatment causes a modest increase in seizure threshold. Synaptic failure time is greatly decreased (25, 26). Taken together, the findings using top1 inhibitors show general consistency among the findings (25, 26). All three inhibitors, CPT, apigenin, and kaempferol, have similar results.
Essential functions of DNA topoisomerase I in Drosophila melanogaster. Dev Biol 2000;222:27–40. Champoux JJ. DNA topoisomerases: Structure, function and mechanism. Annu Rev Biochem 2001;70:369–413. Boege F, Straub T, Kehr A, Boesenberg C, Christiansen K, Anderson A, Jacob F, Kohrle J. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J Biol Chem 1996;271: 2262–2270. Pommier Y, Pourquier P, Fan Y, Strumberg D. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the Drosophila Seizure Models enzyme.
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