By Eugene C. Toy, Jr., William E Seifert, Henry W. Strobel, Konrad P. Harms
Fifty medical instances assist you excel in biochemistry classes and the USMLE Step 1
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Additional info for Case Files: Biochemistry (Lange Case Files), 2nd edition
Frenkel EP, Yardley DA. Clinical and laboratory features and sequelae of deficiency of folic acid (folate) and vitamin B12 (cobalamin) in pregnancy and gynecology. Hematol Oncol Clin North Am 2000;14(5):1079–100. Lin Y, Dueker SR, Jones AD, et al. Quantitation of in vivo human folate metabolism, Am J Clin Nutr 2004;80:680–91. , et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption, Cell 2006;127:917–28. Murray RK, Granner DK, Mayes PA, et al.
C. D. E. 4] refer to the following list of vitamins: A. B. C. D. E. F. G. H. 4], select the vitamin that is most likely to be deficient. 2] A muscular 25-year-old male presents with dermatitis and an inflamed tongue. A history reveals that he has been consuming raw eggs as part of his training regimen for the past 6 months. 3] A 30-year-old male goes to his dentist complaining of loosening teeth. Examination also reveals his gums are swollen, purple, and spongy. The dentist also notes that the patient’s fingers have multiple splinter hemorrhages near the distal ends of the nail and that a wound on the patient’s forearm has failed to heal properly.
However, in situations of folate deficiency, symptoms are not observed from the lack of these products as adequate levels of choline and amino acids are obtained from the diet. ) Folate deficiency results in megaloblastic anemia. Megaloblastic anemia is characterized by macrocytic erythrocytes produced by abnormal proliferation of erythroid precursors in the bone marrow. Folate deficiency encumbers the maturation of these cells by inhibition of DNA synthesis. Without an adequate supply of folate, DNA synthesis is limited by decreased purine and dTMP levels.