By E. Edward Bittar and David R. Colman (Eds.)
One prerequisite for the evolution of multicellular organisms was once the discovery of mechanisms through which cells may possibly adhere to each other. sooner or later in our historical past, dividing cells now not went their separate protozoic methods within the primordial oceans, yet as an alternative discovered that through preserving an organization, through sticking jointly yet now not fusing, a number of evolutionary merits turned attainable. the next improvement of specialised tissues and organs trusted the elaboration of quite subtle, regulatable cell-to-cell adhesion mechanisms that are recognized to function in organic methods as varied because the progress of the embryo, the immune reaction, the institution of connections among nerve cells, and arteriosclerosis, to call quite a few. even though we will in simple terms wager on the ancestral mechanisms that fostered the 1st primitive intercellular unions, a few one thousand million years in the past, we now realize modern molecular "themes" with most likely historic origins that mediate cell-cell interactions. The chapters during this booklet function invaluable, thought-provoking, yet no longer exhaustive, commentaries on modern subject matters in the extensive box of phone adhesion. If the reader detects a mild tilt towards these adhesion molecules that functionality within the fearful procedure, this can be basically a mirrored image of this editor's pursuits, biases, and naturally, obstacles.
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Extra info for Cell Adhesion
The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg2+dependent adhesion of platelets to collagen. J. Cell. Biol. 108, 1917-1924. E. (1989). The primary structure of the VLA-2/collagen receptor ct2 subunit (platelet GP Ia): Homology to other integrins and the presence of a possible collagen-binding domain. J. Cell Biol. 109, 397-407. , & Ginsberg, M. H. (1992). A point mutation of integrin PI subunit blocks binding of 05/31 to fibronectin and invasin but not recruitment to adhesion plaques.
Tissue-specific homing and tissue-specific regulation of adhesion molecule expression are fascinating areas of study, but their review is beyond the intent of this chapter. ) Function and Regulation of Selectins 41 The expression of E-selectin on cytokine-stimulated endothelial cells requires de novo mRNA and protein synthesis. Kinetic analysis has shown that 2-4 h are needed for optimal E-selectin expression on the surface of endothelial cells following cytokine stimulation. , 1987, 1989). , 1991).
Chem. 264, 3588-3595. L. (1991). Signal transduction by integrins: Increased protein tyrosine phosphorylation caused by clustering of /3l integrins. PNAS 88,8392-8396. H. (1980). Structure and evolution of calcium-modulated proteins. CRC Crit. Rev. Biochem. 8, 119-174. M. (1992). Regulation of fibronectin receptor distribution. J. Cell Biol. 117, 4 3 7 4 7 . , Phillips, D. A. (1990). Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene.