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Extra resources for Controversial Geneticist and Creative Biologist: A Critical Review of His Contributions with an Introduction by Karl von Frisch
Johns Hopkins Press (1957). S. S. 47:403 (1961). W. H. S. 47:1588 (1961). P. Lengyel, J. Speyer, and S. S. 47:1936 (1961). C. C. R Helinski, U. S. 51:266 (1964). 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 F. Jacob and J. Monod, J. Mol. BioI. 3:318 (1961). A. Chovnick, W. Gelbart, M. McCarron and B. Osmond, Genetics 84:233 (1976). c. F. Sherald, Genetics 84:287 (1976). L. Miller, Jr. and B. Beatty, Science 164:955 (1969). A. L. , in "Gene Expression and its Regulation", Plenum Press (1971).
Transcribable (functioning) genes are located in the chromomeres, bands, and lampbrush loops, but there is much more DNA in a band than is necessary to code for one gene. We don't know yet the function of the rest of the DNA. Neither do we know the function of the DNA in the interbands or interchromomeric regions. Changes in folding patterns of chromosomes are correlated with genetic activity. DNA loops out from the chromomeres during transcription on lampbrush 100ps34,35 and on "puffed" polytene bands.
DNA loops out from the chromomeres during transcription on lampbrush 100ps34,35 and on "puffed" polytene bands. Transcription (gene function) dwin~les to nothing as cells progress through prophase to metaphase while maximally folding, spiralizing and condensing the chromosomes in readiness for mitotic division. Differences in folding or packing along the length of individual chromosomes were described many years ago by Heitz 36 and were evidenced by differences in cytological staining of the chromosomes.