By Thomas M. Herndon, George C. Tsokos (auth.), Priv.-Doz. Dr. Annegret Kuhn, Prof. Dr. Percy Lehmann, Prof. Dr. Dr. H.C. Thomas Ruzicka (eds.)
Lupus erythematosus is a prolonged inflammatory autoimmune illness characterised by way of a large spectrum of manifestations with a variable evolution. there was a long-standing want for a booklet with a unifying idea at the cutaneous manifestations of this illness. The publication relies on multidisciplinary wisdom and is written via top clinicians and scientists. It presents not just a entire description of the big number of cutaneous abnormalities but in addition a synthesis of the connection among cutaneous and systemic alterations, together with chapters on class and scientific facets, pathogenesis and pathologic gains, and remedy and administration of lupus erythematosus. In precis, the e-book is a crucial source for clinicians and scientists operating within the box of autoimmune diseases.
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Extra info for Cutaneous Lupus Erythematosus
Immunol Today 20:123–128 Tsokos GC, Virella G (2001) Tolerance and autoimmunity. In: Virella G (ed) Medical immunology. Marcel Decker, New York, pp 313–339 Tsokos GC, Boumpas DT (2002) Human systemic lupus erythematosus. In: Theofilopoulos AN, Bona AN (eds) The molecular pathology of autoimmune diseases. Taylor & Francis, Ann Arbor, pp 261–287 Tonegawa S (1983) Somatic generation of antibody diversity. Nature 302:575–581 von Boehmer H (1994) Positive selection of lymphocytes. Cell 76:219–228 18 Thomas M.
An alternative means by which UVB irradiation could have an effect is by inhibiting the phosphorylation of important signal transduction proteins involved in the signaling of these two cytokines. Conclusion Most of the published studies indicate the inhibitory effects of UV irradiation, especially on cellular immune responses. However, UV exposure is also known to induce and activate cell-mediated diseases such as systemic and certain forms of cutaneous LE. Thus, it seems that there is a paradox in the effects of UV irradiation on health.
References Aberer W, Schuler G, Stingl G, Hönigsmann H, Wolff K (1981) Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 76:202–210 Aberer W, Stingl G, Stingl-Gazze LA, Wolff K (1982) Langerhans cells as stimulator cells in the murine primary epidermal cell-lymphocyte reaction: alteration by UV-B irradiation. J Invest Dermatol 79:129–135 Applegate LA, Ley RD, Alcalay J, Kripke ML (1989) Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet irradiation.