Semaphorins: Receptor and Intracellular Signaling Mechanisms by Eric F. Schmidt, Stephen M. Strittmatter (auth.), R. J.

By Eric F. Schmidt, Stephen M. Strittmatter (auth.), R. J. Pasterkamp (eds.)

This e-book info our growth in knowing the receptor and intracellular signaling mechanisms used by a relatives of proteins referred to as the semaphorins. initially those protein have been pointed out as "axon suggestions cues" vital for the formation of nerve tracts yet now it's learned that semaphorins subserve a number of specific features in a large number of organ platforms.

This booklet summarizes our wisdom and makes it on hand as an invaluable and entire instrument for the clinical group. It covers the whole semaphorin box from neurosciences to cardiovascular examine and past, detailing the entire most recent ideas and effects. the great evaluate of semaphorin biology and signaling awarded during this publication permits one to match semaphorin services among assorted organic platforms. The publication should be of curiosity to humans operating within the box in addition to those that paintings in different fields of technological know-how and wish to study extra approximately semaphorins and linked signaling mechanisms.

Show description

Read or Download Semaphorins: Receptor and Intracellular Signaling Mechanisms PDF

Best nonfiction_9 books

LACAME 2006: Proceedings of the 10th Latin American Conference on the Applications of the Mössbauer Effect (LACAME 2006) held in Rio de Janeiro, Brazil, 5–9 November 2006

Court cases of the tenth Latin American convention at the purposes of the Mössbauer impression, LACAME 2006, held in Rio de Janeiro urban, Brazil, 5-9 November 2006. This quantity demonstrates the best way researchers, on a variety of subject matters, many interdisciplinary, locate the purposes of the Mössbauer impact an excellent technique whose effects, occasionally specific, enhances and improves the knowledge bought by means of different strategies to deepen the knowledge of the problem below learn.

Human Cell Culture: Volume VI: Embryonic Stem Cells

If you want to develop or symbolize embryonic stem cells or convince them to tell apart right into a specific telephone sort, then this ebook comprises info that's very important in your luck. the purpose is to supply transparent easy directions and protocols for growing to be, holding and characterizing embryonic stem cells and information of a number of the tools used to make stem cells differentiate into particular mobilephone forms.

X-Ray Fluorescence Spectrometry (XRF) in Geoarchaeology

Because the Sixties, x-ray fluorescence spectrometry (XRF), either wavelength and energy-dispersive have served because the workhorse for non-destructive and harmful analyses of archaeological fabrics. lately eclipsed through different instrumentation corresponding to LA-ICP-MS, XRF is still the mainstay of non-destructive chemical analyses in archaeology, fairly for volcanic rocks, and such a lot fairly for obsidian.

Fluorescence In Situ Hybridization (FISH) — Application Guide

This FISH software consultant offers an outline of the rules and the elemental strategies of fluorescence in situ hybridization (FISH) and primed in situ hybridization (PRINS), that are effectively used to check many elements of genomic habit and adjustments. In 36 chapters, contributed by means of foreign specialists of their specific box, the these days a number of techniques and purposes of the robust thoughts are offered and specified protocols are given.

Additional resources for Semaphorins: Receptor and Intracellular Signaling Mechanisms

Example text

Vikis HG, Li W, He Z et al. The semaphorin receptor plexin-Bl specifically interacts with active rac in a ligand-dependent manner. Proc Natl Acad Sci USA 2000; 97(23): 12457-12462. 54. Zanata SM, Hovatta I, Rohm B et al. Antagonistic effects of Rndl and RhoD GTPases regulate receptor activity in Semaphorin 3A induced cytoskeletal collapse. J Neurosci 2002; 22(2) :471-477. 55. Turner LJ, NichoUs S, Hall A. The activity of the plexin-Al receptor is regulated by rac. J Biol Chem 2004; 279(32):33199-33205.

Among the PI3Ks, the class I group of PI3K is key in the generation of the PIP3 signaling intermediary, leading to activation of Akt/PKB and other downstream effectors. Class I PI3Ks are heterodimers consisting of a regulatory subunit (collectively called *p85s') whose SH2 domain mediates recruitment of the pllO catalytic subunit to membrane-bound receptors, adaptor proteins and Ras. ' ^ Stimulation of the PI3Ks involves binding of p85 to the phosphorylated YXXM motif during growth factor receptor activation.

Phosphorylation is recognised as a fundamental process involved in the regulation of intracellular signaling in response to extracellular signals, and is mediated by a host of intracellidar serine/threonine, tyrosine and lipid kinases. The requirement of kinases in Semaphorin signaling extends from the surface of the cell, at the receptor level, to specific intracellular pathways. In this chapter we will focus on the specific, yet divergent, cellular processes that are achieved through modulation of the enzymatic activity of key intracellular kinase pathways (Fig.

Download PDF sample

Rated 4.93 of 5 – based on 42 votes