SialoGlyco Chemistry and Biology I: Biosynthesis, structural by Rita Gerardy-Schahn, Philippe Delannoy, Mark von Itzstein

By Rita Gerardy-Schahn, Philippe Delannoy, Mark von Itzstein

The sequence issues in present Chemistry offers serious stories of the current and destiny tendencies in sleek chemical examine. The scope of assurance is all parts of chemical technological know-how together with the interfaces with similar disciplines resembling biology, medication and fabrics technological know-how. The target of every thematic quantity is to provide the non-specialist reader, even if in academia or undefined, a complete perception into a space the place new examine is rising that's of curiosity to a bigger medical viewers. each one overview in the quantity severely surveys one element of that subject and areas it in the context of the quantity as an entire. the main major advancements of the final five to ten years are provided utilizing chosen examples to demonstrate the rules mentioned. The insurance isn't meant to be an exhaustive precis of the sector or comprise huge amounts of information, yet may still otherwise be conceptual, focusing on the methodological considering that may let the non-specialist reader to appreciate the knowledge provided. Contributions additionally supply an outlook on capability destiny advancements within the box. assessment articles for the person volumes are invited by means of the quantity editors. Readership: learn chemists at universities or in undefined, graduate students

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Extra info for SialoGlyco Chemistry and Biology I: Biosynthesis, structural diversity and sialoglycopathologies

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3. The gene is homologous to the CAS1 gene of Cryptococcus neoformans. The designation is derived from the function of its encoded protein in the formation of the fungal Functions and Biosynthesis of O-Acetylated Sialic Acids 21 Capsule Structure. Genetic evidence strongly indicates that the fungal Cas1 protein is involved in the O-acetylation of glucorono-xylomannans [182]. Deletion of the CAS1 gene resulted in a loss of O-acetylation on C-6 of either Man or ManGlcA residues. O-Acetylation could be restored by expression of CAS1 from a plasmid.

Ravindranath MH, Muthugounder S, Presser N (2008) Melanoma Res 18:47 129. Gocht A, Rutter G, Kniep B (1998) Histochem Cell Biol 110:217 130. Cao Y, Merling A, Crocker PR, Keller R, Schwartz-Albiez R (2002) Lab Invest 82:1515 131. Claus C, Schlaak J, Dittmayer M, Meyer zum Buschenfelde K, Dippold W (1994) Eur J Immunol 24:1208 132. Malisan F, Franchi L, Tomassini B, Ventura N, Condo I, Rippo MR, Rufini A, Liberati L, Nachtigall C, Kniep B, Testi R (2002) J Exp Med 196:1535 133. De Maria R, Lenti L, Malisan F, d’Agostino F, Tomassini B, Zeuner A, Rippo MR, Testi R (1997) Science 277:1652 134.

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 33 35 36 37 38 39 39 40 40 41 42 42 43 44 45 45 45 45 46 46 47 47 47 48 48 48 49 1 The Evolutionary Origins of Sialic Acids Sialic acids (Sias) commonly occupy the terminal position on the glycoconjugates that cover all vertebrate cell surfaces, and as such are major determinants of the molecular cell surface phenotype [1].

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